Intoxicated Na+ channels. Focus on “Ethanol stimulates epithelial sodium channels by elevating reactive oxygen species”
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چکیده
منابع مشابه
Cyclosporine stimulates the renal epithelial sodium channel by elevating cholesterol.
Cyclosporine A (CsA) is an efficient immunosuppressant used for reducing allograft rejection but with a severe side effect of causing hypertension. We hypothesize that the renal epithelial sodium channel (ENaC) may participate in CsA-induced hypertension. In the present study, we used the patch-clamp cell-attached configuration to examine whether and how CsA stimulates ENaC in A6 distal nephron...
متن کاملEpithelial Na Channels
Epithelial Na channels mediate Na reabsorption in the distal segments of the kidney, gut, and other organs (Garty and Palmer, 1997). They are vital to the control of blood volume and arterial blood pressure, as evi-denced by various forms of hypertension involving defects in the channels themselves or the renin–angio-tensin–aldosterone axis regulating them (Lifton, 1996). Several years ago the ...
متن کاملEpithelial Na(+) channels are regulated by flow.
Na(+) absorption in the renal cortical collecting duct (CCD) is mediated by apical epithelial Na(+) channels (ENaCs). The CCD is subject to continuous variations in intraluminal flow rate that we speculate alters hydrostatic pressure, membrane stretch, and shear stress. Although ENaCs share limited sequence homology with putative mechanosensitive ion channels in Caenorhabditis elegans, controve...
متن کاملEndogenous reactive oxygen species modulates voltage-gated sodium channels in dorsal root ganglia of rats.
We recently reported that reactive oxygen species (ROS) plays an excitatory role in modulation of the exercise pressor reflex (EPR) in normal rats. In this study, we further tested two independent hypotheses: 1) ROS interacts with EPR-related ionotropic receptors such as the purinergic receptors (P(2)) and transient receptor potential vanilloid 1 receptors (TRPV1) to indirectly modulate the EPR...
متن کاملEpithelial sodium channels and hypertension.
Hypertension is a major risk factor for heart attacks, stroke, and kidney failure. It is estimated to cause as many as 25% of all deaths in the United States, particularly for African Americans, in whom the disease is both more common and more severe. Essential hypertension is a multifactorial disorder influenced by both genetic and environmental factors. Physiological studies have shown that t...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2012
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00301.2012